Swapan Jain

Swapan Jain

Associate Professor of Chemistry
Director, Chemistry Program
Biochemistry

Office: Reem Kayden Center 134
Phone: 845-752-2354
E-mail: sjain@bard.edu
Link to Professional Website

Education

  • Postdoctoral Research Fellow, Boston University (2009)
    • Research Advisor:  Prof. Thomas Tullius
  • PhD, Biochemistry, Georgia Institute of Technology (2006)
    • Research Advisor: Prof. Nicholas Hud
  • BS, Chemistry & Biology, Kennesaw State University (2001)
    • Research Advisors: Prof. Jennifer Powers and Prof. Kenneth Hughes

Courses

  • Basic Principles of Chemistry I (Chem 141)
  • Basic Principles of Chemistry  II (Chem 142)
  • Biochemistry (Chemistry 390)
  • Analytical and Physical Laboratory Techniques (Chem 350)
  • Structure and Function of Nucleic Acids (Chem 441)

Research Interests


The focus of our research group is to understand the interactions of small molecule ligands with RNA and DNA.  Specifically, we are investigating the binding of transition metal complexes as well as purine analogs to RNA and the role that these molecules play in modulating RNA structure as well as genetic expression.


Research Projects

  • RNA has a three-dimensional folded structure that parallels the complexity of proteins. Riboswitches are regions in mRNA that control genetic expression upon binding of ligands. Our goals in this project are to identify structural changes that occur at the single base level upon binding of ligands to RNA. Specifically, we want to take a closer look at mRNAs involved in the purine metabolic pathways.
  • RNA interactions with transition metal complexes containing ruthenium, iron, and platinum are studied using a variety of chemical, physical, and biological tools with the pursuit of obtaining novel and effective chemotherapeutics.

Selected Publications (undergraduate authors underlined, Bard students denoted with *)

  1. 2016:    Sunderland, J., Tao, X., Butrick, E., Keilich, L., Villa, C., Miecznikowski, J.R., Jain, S.S.  Investigation of liver alcohol dehydrogenase catalysis using an NADH biomimetic and comparison with a synthetic zinc model complex. Polyhedron, 114, 145-151.
  2. 2015:   Jain, S.S., Sonavane, U., Uppuladinne, M., McLaughlin, E.C., *Weiqing, W., *Black, S., Joshi, R.R. “Structural Insights into the Interactions of xpt Riboswitch with Novel Guanine Analogues: A Molecular Dynamics Simulation Study” J. Biomolecular Structure and Dynamics  33 (2), 234-243.
  3. 2015:    Anderson, C.M., Jain, S.S., *Silber, L., *Chen, K., *Guha, S., *Zhang, W., McLaughlin, E., Hu, Y., Tanski, J. “Synthesis and Characterization of Water-Soluble, Heteronuclear Ruthenium(III)/Ferrocene Complexes and Their Interactions with Biomolecules”. J. Inorganic Biochemistry 145, 41 - 50.
  4. 2014:   Ingle, S., Azad, R., Jain, S.S., Tullius, T.D. “Chemical Probing of RNA using the hydroxyl radical at single-atom resolution” Nucleic Acids Research 42 (20), 12758 - 12767.
  5. 2013:  Jain, S. S., Anderson, C. M., *Di Rienzo, F., *Taylor, I., *Jain, K., *Guha, S., *Hoque, N. “RNA Binding and Inhibition of Primer Extension by a Ru(III)/Pt(II) Metal Complex” Chemical Communications 49, 5031 – 5033. 
  6. 2013:  Jain, S. S., LaFratta, C. N., *Medina, A., *Pelse, I. “Proflavine-DNA Binding using a Handheld Fluorimeter” J. Chem. Ed. 90, 1215-1217.
  7. 2013:   Miecznikowski, J.R., Lynn, M.A., Jasinski, J., Jain, S.S., Buttrick, Drosdoski, Archer, Panarra, “Synthesis, Characterization, Density Functional Theory Calculations, and Activity of Tridentate NNN Zinc Pincer Complexes” Inorganica Chimica Acta 394, 310-321.
  8. 2013:  LaFratta, C.N., Jain, S. S., *Pelse, I., *Simoska, O., Elvy, K. Using a Homemade Flame Photometer to Measure Sodium Concentration in a Sports Drink” J. Chem. Ed. 90, 3, 372 – 375.
  9. (2012)  Miecznikowski, J.R., Lo, W., Lynn, M.A., Jain, S.S., Keilich, L.C., Kloczko, N.F., O’Loughlin, B.E., DiMarzio, A., Foley, K.M., Lisi, G.P., Kwiecien, D.J., *Abbasee, R. “Synthesis, Characterization, Density Functional Theory Calculations, Biochemical Assays and Activity of Tridentate SNS Zinc Pincer Complexes Based on Bis-Imidazole or Bis-Triazole Precursors” Inorganica Chimica Acta. 387, 25-36.
  10. (2008)  Jain, S.S., Tullius, T.D. “Footprinting Protein-DNA Complexes using the Hydroxyl Radical” Nature Prot. 3, 1092-1100.
  11. (2007)  Hud, N.V., Jain, S.S., Li, X., Lynn, D.G., “Addressing the Problems of Base Pairing and Strand Cyclization in Template-Directed Synthesis Reactions” Chemistry & Biodiversity. 4, 768-783.
  12. (2005)  Powers, J.L., Andrews, C.S., St. Antoine, C.C., Jain, S.S., Bevilacqua, V.L., “An SDS-PAGE Examination of Protein Quaternary Structure and Disulfide Bonding for a Biochemistry Laboratory” J. Chem. Ed. 82, 93-95.
  13. (2004)  Persil, Ö, Santai, C.T., Jain, S.S, Hud, N.V., "Assembly of an Antiparallel Homo-Adenine DNA Duplex by Small Molecule Binding" J. Am. Chem. Soc. 126, 8644-8645.
  14. (2004)  Jain, S.S., Anet, F.A.L., Stahle, C.J., Hud, N.V., “Enzymatic Behavior by Intercalating Molecules and their Putative Role in the RNA World” Angew. Chem. Int. Ed. 43, 2004-2008.
  15. (2003)  Jain, S.S., Polak, M., Hud, N.V., “Controlling Nucleic Acid Secondary Structure by Intercalation: Effects of DNA Strand Length on Coralyne Driven Duplex Disproportionation” Nucleic Acids Res. 31, 4608-4615.
  16. (2002)  Bevilacqua, V.L.H., Powers, J.L., Vogelien, D.L., Rascati, R.J., Hall, M., Diehl, K., Tran, C., Jain, S.S., Chabayta, R., “Collaboration between Chemistry and Biology to Introduce Spectroscopy, Electrophoresis, and Molecular Biology as Tools for Biochemistry” J. Chem. Ed. 79, 1311.

Current Research Students in the Jain Lab (with expected graduation year)

  •  Miguel Garchitorena     2017
  • Tamaki Chiba                2017
  • Madeleine Breshears   2018
  • Hang Hoang                 2018
  • Humam Al Rubaiye      2019

Senior Thesis Projects (with graduation year and current position)

  • Nicholas Wilton           2010                  Ph.D. from Tufts University.
  • Stavros Vellisaris        2011                  Medical student at St. George’s Medical School in Cyprus
  • Angela Potenza          2011                 University of Pennsylvania Veterinary School student.
  • Jing Yang                   2012                 Graduate student at University College London.
  • Weiqing Wang           2013                 Ph.D. student at Mt. Sinai School of Medicine.
  • James Sunderland    2013                 Teacher, Chemistry and English in Brazil.
  • Sheneil Black            2013                 Currently applying to dental schools.
  • Wancong Zhang       2013                 Research Associate at MIT.
  • Iden Sapse               2014                Research Associate at Weill Cornell Medical School.
  • Lila Low-Beinart       2014                Research Associate at Merck Pharmaceuticals.
  • Nushrat Hoque        2014                Currently applying to graduate schools.

 

External Grants for Undergraduate Research

  • Research Corporation  2012                $ 45,000
  • Dreyfus Foundation     2013                $ 18,500

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